Olfactory nerve and Optic nerve ( The cranial nerves I and II )

Organization of the cranial nerves

Sensory nerves

Motor nerves

Mixed nerves

  1. Olfactory
  2. Optic
  3. Vestibular – cochlear
  4. Occulomotor
  1. Trochlear
  2. Abducent
  3. Accessory
  4. Hypoglossal
  5. Trigeminal
  1. Facial
  2. Glossopharyngeal
  3. Vagus

 

Motor nuclei of the cranial nerves

 

Somatic motor nuclei

General visceral motor nuclei

  1. They receive impulses from the cerebral cortex trough Cortico – nuclear fibers
  2. These fibers originated from the pyramidal cells of the inferior part of the pre central gyrus (Area 4) & the adjacent part of the post central gyrus
  3. The fibers descend through the corona radiate & genu of the internal capsule
  4. They pass through the midbrain just medial to the corticospinal fibers & synapse with the cranial nerve nuclei
  5. Bilateral connections are present for all cranial motor nuclei except for:
    1. Part of the facial nucleus that supplies the muscles of the lower part of the face
    2. Part of the hypoglossal nucleus that supplies the genioglossus muscle
    3. They form the cranial outflow of the parasympathetic part of the ANS
  1. Edinger Westphal nucleus (III nerve)
  2. Superior salivatory & Lacrimal nuclei (VII nerve)
  3. Inferior salivatory nucleus                (IX nerve)
  4. Dorsal motor nucleus (X nerve)

 

1) Olfactory nerve

Olfactory nerve

  • It’s a sensory nerve : Sensation of smell
  • Olfactory receptor : 1st order neuron
  • Nerves fibers
  • Unmyelinated & runs through the cribriform plate of the ethmoid bone
  • Doesn’t pass through the thalamus (No connection with thalamic nuclei)
  • Olfactory area of the cerebral cortex is area 28

 

 

 

 

Examining the olfactory nerve

  • Use a common bedside substance like soap, fruit or etc to each nostril separately (Close the other)
  • Don’t use irritable substance like NH3 (It will stimulate TGN – V)
  • Defects
  • Anosmia : Absence of smell (Sub frontal meningioma, head injury, Craniotomy & Catarrh – Inflammation of the mucus membranes)
  • Hallucinations of smell : in temporal lobe seizures

 

 

2) Optic nerve

Optic nerve

Parts of the optic pathway

Part

Explanation

1)      Origin of the optic nerve
  1. Fibers of the optic nerve are the axons of the ganglionic layer of the retina
  2. They converge on the optic disc & leave the eye as the optic nerve
  3. Fibers of the optic nerve are myelinated (By oligodendrocytes)
  4. Optic nerve leaves the orbital cavity through the optic canal
2)      Optic chiasma
  1. The fibers from the nasal ½ of each retina (Including the nasal ½ of the macula) cross the midline enter the optic tract opposite side
  2. The fibers from the temporal ½ of each retina (Including the temporal ½ of the macula) pass to the optic tract of the same side
3)      Optic tract
  1. Emerges from the optic chiasma
  2. Most fibers synapse with nerve cells in the LGB
  3. Few fibers pass to the pretectal nucleus & the superior colliculus of the midbrain are responsible for light reflexes
4)      Lateral geniculate body (LGB)

It’s a thalamic nucleus

5)      Optic radiation
  1. It’s the axons of the nerves of LGB
  2. Pass through the internal capsule & terminates in the visual cortex (Area 17 – Occupies the upper & lower lips of the calcarine sulcus)
  3. Visual association area (Area 18 & 19) are responsible for recognition of objects & perception  of color
6)      Neurons of the visual pathway
  1. Rods & Cones (Specialized receptor neurons in the retina)
  2. Bipolar neurons (Connect the rods & cones to ganglion cells)
  3. Ganglion cells (Axons pass to the LGB)
  4. Neurons of the LGB (Axons pass to the cerebral cortex)

 

The visual reflexes

A. Direct & consensual light reflexes – Pathway

imageDirect & consensual light reflexes – Pathway

 

 

B. Accommodation reflex

 

When the eyes are directed from a distant object to a near object:

1. Medial recti contracts (Brings convergence)

2. Lens thickens to increase the refractory power by contracting ciliary muscles

3. Pupils constrict to restrict light waves to the thickest central part of the lens

 

The pathway

image

 

C. Corneal reflex : Light touching of the cornea or conjunctive results in blinking of the eye lids

Cornea or Conjunctiva

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Ophthalmic branch of the TGN

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Main sensory ganglion of the TGN

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Internuncial neurons connect with the motor nucleus of the facial nerve on Both sides (Through the medial longitudinal fasciculus)

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Facial nerve

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Orbicularis oculi of both sides

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Closure of the eyelids

D. Visual body reflex

Visual impulse

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Optic tract

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Superior colliculus

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Tectospinal & Tectobulbar (Tectonuclear) fibers Neurons of the anterior grey columns of the spinal cord & cranial motor

Effects of visual body reflexes

 

1. Automatic scanning movements of the eyes & head that are made when reading

2. Automatic movements of the eyes, head & neck towards the visual stimulus

3. Protective closing of the eyes & raising arm for protection

 

Examination of the optic nerve

Visual acuity
  1. By a Snellen’s chart held at 6m from the patient (if space is limited at 3m with a mirror)
  2. Acuity greater than 6/60 is dependent on the macular vision
  3. Each eye is tested separately
  4. If the patient cannot see the largest (Designated 60), reduce the test distance
  5. If at 1m ‘60’ letter cannot be read, use:
    1. Counting fingers held up at 1m
    2. Hand movements
    3. Perception of light
    4. If a patient cannot read 6/6 check the vision again using a pinhole occluder (Only the central light pass to the retina) – Can differentiate patients with poor vision due to:
      1. Refractory errors (Myopic – Short sighted, Hypermetrophia – Long sighted, Astigmatism – Cornea is not uniformly curved & light is not evenly focused on the retina)
      2. Ocular or neurological conditions
Visual field
  1. Moving finger test
    1. The finger should be kept more than midway between you & the patient
    2. Patient closes one eye & fixes the gaze on your eye
    3. Red pin confrontation test
      1. Use a red hatpin (d = 0.5cm) held at equidistance between you & the patient
      2. Use exactly same conditions above
      3. Check whether the patient & you see the pin at the same time
      4. Binocular testing
Color vision
  1. Acquired defects
    1. Red color vision can be affected in optic nerve disease & macular disease
    2. Use a red target & check the difference of vision in both eyes separately
    3. Congenital defects          : Use a Ischihara color vision test
Funduscopy Use check:

  1. Papilloedema
  2. Optic atrophy
  3. Pigmentary retinal degeneration
  4. Vascular diseases

The reticular formation,limbic system and basal ganglia

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The structure & functional localization of the cerebral cortex

1) Cerebral cortex is composed of grey matter (10 billion neurons are present) 2) Types of cells present in the cerebral cortex Cell type Special points Pyramidal cells Cell bodies are pyramidal shape Largest cell type Found in the precentral gyrus of the frontal lobe Axons enter the white matter Present throughout the levels of … Continue reading

The cerebrum

1) It’s situated in the anterior & middle cranial fossae 2) Cerebrum is divided into 2 parts 1. Diencephalon : Forms the central core 2. Telencephalon : Forms cerebral hemispheres   A. The diencephalon   1) It’s a midline structure with symmetrical right & left halves 2) It can be divided into 4 major parts … Continue reading

The blood supply of the brain

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The cerebellum

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The midbrain

1) 2 cm in length 2) It connects the pons & the cerebellum with the forebrain 3) It’s traversed by a narrow channel called cerebral aqueduct (Filled with CSF) 4)The anterior surface 1. There’s a deep depression in the midline (Inter peduncular fossa) 2. Inter peduncular fossa is bounded on either side by the crus … Continue reading

The pons

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Brain Stem and Medulla oblongata

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Descending tracts

Descending tracts have 3 neurons 1. 1st order neurons (UMN) : Cell bodies are in the cerebral cortex & other supra spinal areas 2. 2nd order neurons : Short & situated in the anterior grey column of the spinal cord 3. 3rd order neuron (LMN) : Situated in the anterior grey column & innervate the … Continue reading